I’m glad to hear that stuff like this is still going on. Nice!
Wow, this is really exciting. I guess it’ll take years more research before we’ll know if this can benefit humans, but if they can replicate the results with humans then it could potentially prevent chronic pain and mobility issues in millions of people.
Probably worth adding “in mice” to the title
And human tissues, and it’s been shown to be safe in phase I trials.
So saying “in mice” undersells where they are at.
This is not the xkcd I thought you were going to use
This would be amazing for my wife. I mean I guess it would have been amazing if she still had her original knee. Maybe it’ll be amazing for the other knee one day.
Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it’s time we start getting serious about anti-aging and life extension.
But probably not, seeing what the world is like.
People have been seeking life extension for all of recorded history.
Its mostly billionaires who will be able to benefit from life extension… do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?
Luckily there’s no vaccine against guillotines.
Give it time.
Aroooooo
Billionaires, and everybody living outside the US
So essentially Altered Carbon?
I think that’s more kinda digitised, transferable consciousness. I’d take it tho.
deleted by creator
Why do you think that? We already benefit from life extension. And why only 300?
If you’re that worried, start working towards killing them. Seems like it’s going to be necessary step either way to correct many problems in the world. What’s one more reason for the pyre?
How about not life extension but quality of life extension instead (e.g. this post)
Indeed, I don’t really feel like living for more more than 90 years, I just want to be able to do what I like to do until I die.
I didn’t realize people weren’t being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.
LOL that pays for a focus group for branding. You can’t be serious.
I remember when I was a senior in high school back in the late 90s, my biology teacher mused one day that ours might be the first generation to not die of old age. I don’t know if I’m anywhere near as optimistic now as he was then, but it is incredibly exciting to think about. There have been a slew of discoveries over the past 20 years that have been building towards this, and it’s all been very fascinating. No idea if this is the grail or not, but it certainly seems like an important piece of the puzzle.
my biology teacher mused one day that ours might be the first generation to not die of old age.
Good for you that it was not the history teacher.
not dying of old age is a stretch. probably not dying young of certain diseases has improved.
Americans, we get it, you have no healthcare system worth the name. Stop assuming nobody else worldwide can get the meds either.
Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.
The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn’t matter how much it costs.
Or maybe you could show a little sympathy once in a while
America did this shit to itself
And the civilised world gets dragged into the bullshit
And before you whine, the majority of Americans are a part of the problem in one way or another
Your society (for want of a better term) has gotten what it collectively wants
You try running into comments thinking they’re the only nation on earth in every health article and see how long you stay sympathetic.
Sorry, is this not meant to sound like you’re a Eurocentrist douchebag? Medical care and resources are already not distributed proportionately throughout the world exactly because a small number of nations benefit from a brutally extractive colonial system that requires the dehumanization of other groups to exist.
The US doesn’t have a fucking healthcare system because it is a settler-colonial, imperialist military power that holds up the capitalist system that Europeans are such proud benefactors of. They violently enforce a system that inflicts as much precarity and vulnerability as possible on its people because it depends on preventing as many unprivileged people as possible from gaining enough resources to muster an effective challenge to its power within the metropole while maintaining its legitimacy to its more privileged working classes.
So, what the fuck are you bitching about? Americans saying that people won’t be able to afford it? They’re correct, most people will not have access to it so that fucks like you can thanks to the US guarding the loot. Fuck’s sake with you people.
Edit: Before any Euros try to bitch and whine about how unfair it is that you’re still colonizers, I do not care. I don’t fucking care. We are not going to do this thing where you can bitch about the US and pretend like you aren’t world destroyers for the same exact fucking reason it is. If you are not critical of how many EU and European settler nations have the wealth to sustain a healthcare system and quality of life that makes access to medicine an entitlement instead of a privilege, you’re not a serious person.
Australian here
Fuck off with your whining
You idiots did this to yourselves, ironically as a collective, because of your worship of the individual over society
Suck it, yank.
I’m Asian. My country was colonised by Europeans till half a century ago.
Keep going, this is funny. We’ve gone from ‘America is the only nation on earth’ to ‘oh yeah, Europe exists too’.
I’m Eastern European, my country was exploited by USSR until less than 40 years ago. My bad for getting excited about the prospect of being able to walk in old age, it’s all my fault for -checks notes- joining a freedom of trade and movement organisation
You imperialist coloniser superpower douchebag!
my country was exploited by USSR
Do you have a source for that? The inefficiencies of Communism and the lack of cheap third world resources is not the same as being colonised or post-colonised like a third world country.
I’m not entering the exploitation olympics here, feel free to disregard my argument if Eastern Europe doesn’t clear the suffering threshold in your book.
Not necessarily what you’re looking for, but provides some interesting context for others
Maybe orioler25 will figure out that there’s more to the world than only the US and EU :D
Doubtful
Waaah they called out my US defaultist ass and now I need to crash out that the Euros built functioning societies waaaaaaaah
When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]
Sounds very promising! I couldn’t figure out the peer-reviewed-ness status.
Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).
in mice though, since none of these recent one works in humans yet.
This and then the new about regrowing teeth. Its a very exciting time in medicine.
If you think anyone but the elite will be able to afford or procure these procedures, you’re incredibly optimistic.
As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.
“Everything sucks.”
Boring.
This drug can be delivered via pill. It has a range of effects in reversing age related damage.
I’m not sure if it will be kept to the rich, or given out widely to justify the removal of social security, or at least jacking up the retirement age.
Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose…
If the worker-slaves live longer, you don’t have to indoctrinate & capture new ones quite as often!
I’d like my partners knees to work again so they can do the things they like as they age, like riding bikes or hiking.
So… anywhere but the USA it will be affordable(ie free) anyways? Okay.
Bremonia will have the procedures, for free. The name can be changed, I don’t care. I just need help overthrowing a few corrupt governments and I’m out.
Lol Yankee problems
I’m not a Yankee, but thanks for assuming
You’re an American, that’s what Yankee means to everybody outside the states.
I’m old school American
#landback!!!
Are you seriously also down here saying racist shit to a Native American so that you can roleplay some flex on what you thought was just some poor USAmerican who couldn’t afford healthcare? Your good guy scenario was dunking on a poor person in an authoritarian state?
Europeans are seriously the most bloodthirsty fucks I’ll see online, and they’re predictably the most smug about it too.
I have no idea what you’re trying to say. Are you saying he’s NOT an American because he’s indigenous? And wtf is racist? At least now I know what his comment means. You people think everybody knows the same things you do.
(I’m Asian BTW, but yeah go on)
deleted by creator
Ready for someone to tell me why this unfortunately won’t work / become mainstream
Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.
Because PDGH-15 also causes age related muscle weakness.
Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.
I don’t know if the results of the phase 1 trials have been published yet, but it’s been a while since I checked.
I’ve been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.
Money, usually. Or cancer. God i sound depressing 😄
Money cancer.
Ah, the billionaires again.
Finally some good fucking news.
I’m in this thumbnail and I want that right now.
Just in time for me to get old!
Wrong end of the stick, as usual
Amazing!
