Too dangerous for me.
Too much room for error.

Don’t use them.
Very easy to pick SMR HDDs by accident.
You don’t want those inside a NAS.

Set it up on my uGreen DXP4800+
The most unpleasant thing was to configure the LED health indicator and learning how it works.

Regarding NAS loudness volume: I can give you some advice as mine is in my bedroom.
Choose quiet drives. I deployed 4x Toshiba N300 15TB He HDDsin RaidZ2
Maybe mod the drive cages: Use something like sticly velcro strips (soft side) on all sides that HDD/caddies touch the caddy and case/chassie.
Move your intensive access times to late night (4am for example) or when you are at work/gone from home.
Use a soft surface. I have placed the NAS on soft foam from packing materials to reduce vibrations.

Happy storing :)

Imagine having to back up 50Tb to S3 :p
Not everyone has a symmetric connection.

The tape drive costs more or less 2000€ (without VAT), the tapes cost about 80-100 for a 15tb drive (and compressed capacity doesnt count as the to be backed up data is probably not just a database or text.

Don’t think there are much economic options beside finding the cheapest S3 storage or a secondary backup server.